🍹 (1/2) Alcoholism contributes to hematologic disorders, including anemia, leukopenia, and thrombocytopenia. Alcoholic Megaloblastic Anemia is likely multifactorial. Alcohol directly and indirectly decreases absorption, increases urinary excretion, and alters metabolism disrupting folate hemostasis.
Folate is crucial for DNA synthesis. In the setting of folate deficiency, folate targets rapidly proliferating cells from bone marrow and gastrointestinal tract. This results in suppression of blood cell production and prevention of maturation into functional cells. Patients are at high risk of iron and folate deficiencies from poor intake and/or effects from chronic alcoholism. Impaired red blood cells cannot carry oxygen at full capacity, thats kind of important.
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Mark Nguyen, PharmD, BCEMP